Jhpiego has drawn upon its global experience in scale-up of large public health programs, training and mentoring of community health workers, disease investigation and vaccines delivery to provide training, technical assistance and program management support to the Baltimore City Health Department’s COVID-19 response. As part of the innovative, multi-partner Baltimore Health Corps Initiative launched in June 2020, Jhpiego supported the hiring, deployment and training of more than 200 contact tracers, all of whom had lost their jobs or had their work substantially affected due to the economic fallout of the pandemic. With the arrival of COVID-19 vaccines in December 2020, Jhpiego’s role expanded to: developing a training for vaccination workers; building a team of community health workers for mobile vaccination clinics; and hiring a team of people to support, manage and advise a community-centered vaccine outreach and education response, also known as COVAX.