Reaching Impact, Saturation, and Epidemic Control

Enhancing global health by ensuring local capacity to meet health emergencies

USAID’s Reaching Impact Saturation and Epidemic Control (RISE) program has supported over 20 countries across the globe with technical assistance, service delivery, research, and cross-cutting health system aid.

RISE utilizes proven tactics from 20 years of PEPFAR implementation to address critical HIV and COVID-19 priorities and to further meet the demands of global health security. RISE is a multi-year project running through 2025, with an award ceiling of $391 million.


Provider Training Toolkit on use of Long-acting Injectable Cabotegravir (CAB-LA) for HIV Pre-Exposure Prophylaxis (PrEP)

The training and resources included in this toolkit will help clinicians learn about and support provision of CAB-LA as an HIV prevention option for their clients.


Of the approximately 37.9 million people living with HIV, 1.7 million were newly infected in 2018—510,000 of them between the ages of 10 and 24.

About RISE

RISE, a 5-year global project funded by the U.S. President’s Emergency Plan for AIDS Relief (PEPFAR) and the U.S. Agency for International Development (USAID), allows USAID missions to access direct service delivery and technical assistance to achieve their PEPFAR targets. RISE is ready to mobilize our in-country teams to help USAID achieve country operational plan targets across the HIV prevention, care and treatment cascade. RISE focuses on eight key technical areas:

Smiling woman at desk going through paperwork
Photo by Monique Jaques

Health Systems Strengthening 

We work with stakeholders at all levels of the health care system to identify needs and mobilize resources to build high-quality, resilient and locally owned systems.

Clinician working with a patient
Photo by Monique Jaques

HIV Prevention

We introduce and scale up evidence-based solutions to break the cycle of HIV transmission and reach those at highest risk for HIV.

Download the Oral PrEP Brief Download the VMMC Brief Download the VMMC Online Training Hub Brief
Health care worker handling an HIV testing kit
Photo by Monique Jaques

HIV Testing

We support countries to provide comprehensive HIV testing services, including facility- and community-based testing, index case testing and self-testing, and link those who test positive to care and ART initiation.

Download the HIV Testing Services and Linkage Brief
Clinician holding a box of antiretroviral medication
Photo by Monique Jaques

Antiretroviral Optimization 

We partner with countries to support the transition to optimized ART regimens, initiate and scale up differentiated models of care, and promote adherence and retention in care to achieve and maintain viral suppression.

Download the ART Optimization Brief
Clinician gesturing toward a wall chart while a patient observes
Photo by Monique Jaques

Strategic Information 

We work with countries to strengthen system capacity for responsive reporting and data use, including integration across national, subnational and site-level systems, as well as high-frequency reporting.

Download the Strategic Information Brief
Smiling man
Photo by Monique Jaques

Key Populations

We join with communities and stakeholder advocacy groups to identify the needs and priorities of key populations and tailor our impactful, innovative, evidence-based services to their unique needs.

Download the Key Populations Brief Download the Engaging Men in HIV Testing and Care Brief
Health care worker and a patient during a consultation
Photo by Monique Jaques

TB/HIV Integration

We ensure integration and accessibility of HIV and TB services so all clients are tested or screened and linked to appropriate follow-up services.

Download the TB/HIV Integration Brief
Clinician in lab
Photo by Monique Jaques

Laboratory Services

We partner with governments and stakeholders to strengthen the quality, safety and efficiency of lab services and work with country partners to strengthen laboratory policies, infrastructure, systems and personnel.

Download the Laboratory Services Brief

RISE Consortium

PEPFAR
USAID
Jhpiego
ICAP
 Management Sciences for Health
ANOVA Health Institute
BAO Systems
JHU Center for Public Health and Human Rights
Mann Global Health