RISE: Reaching Impact, Saturation and Epidemic Control

Building local capacity for holistic HIV epidemic control and flexible infrastructure to meet the demands of the global health agenda

USAID’s Reaching Impact Saturation and Epidemic Control (RISE) program has supported almost 25 countries across the globe with technical assistance, service delivery, research, and cross-cutting health system aid. RISE utilizes proven tactics from 20 years of PEPFAR implementation to address critical HIV and COVID-19 priorities and to further meet the demands of the Global Health Security Agenda. RISE is a multi-year project running through 2025, with an award ceiling of $391 million.

HIV Epidemic Control

Supporting countries to achieve and
maintain epidemic control.

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COVID-19 Priority Responses

Timely, flexible and culturally
appropriate COVID-19 interventions.

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Global Health Security

Capacity building to Prevent, Detect,
and Respond to emerging health threats.

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Where RISE Works

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RISE Achievements

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Prevent HIV Transmission with CAB-LA

Provider Training Toolkit on use of Long-acting Injectable Cabotegravir for HIV PrEP

The RISE provider toolkit is a vital resource to introduce CAB-LA to PrEP providers in PEPFAR-supported countries. It is designed to help clinicians learn about and support provision of CAB-LA as a new biomedical HIV prevention option.

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Find resources to respond to public health emergencies

  • Basic Emergency Care
  • Vaccines
  • Oxygen Infrastructure

Visit the RISE COVID-19 webpage for technical briefs, job aides and other resources created by RISE teams across the globe

Our Resources

Of the approximately 39 million people living with HIV, 1.3 million were newly infected in 2022. An estimated 5.5 million people did not know they were living with HIV in 2022.

HIV epidemic control

RISE advances HIV epidemic control through prevention, care and treatment. In December of 2022, 29.8 million people were accessing antiretroviral therapy, up from less than 8 million in 2010. New HIV infections have been reduced by 59%, and AIDS-related deaths reduced by 69% since their peak. RISE continues to contribute to this astounding legacy of progress.

Mothers assisting Mothers in Burundi Index Testing for HIV Case Finding Proven Ways to Include Men

Global Health Security

RISE stands ready to support stakeholders to prepare for and remediate public health emergencies of international concern.

Kenya Leads in Basic Emergency Care Ecuador’s COVID-19 Laboratory Response


System-focused strategies that are responsive, holistic and flexible in the face of each country’s specific circumstances.

Ecuador Builds Post-COVID-19 Clinics RISE Responds in Rwanda Hypoxia in Emergency Care

65% of countries lack a national public health emergency response plan for diseases with epidemic or pandemic potential.

RISE Consortium

 Management Sciences for Health
ANOVA Health Institute
JHU Center for Public Health and Human Rights

RISE is funded with support from the U.S. President’s Emergency Plan for AIDS relief and the American Rescue Plan Act, through the United States Agency for International Development, under the terms of the cooperative agreement 7200AA19CA00003. The contents are the responsibility of the RISE program and do not necessarily reflect the views of USAID or the United States Government.